This paper has a title that’s easy to figure out 🙂 .
It’s very useful in explaining the mechanism of insulin resistance, the role of the liver, influence on diabetes, and more recently/importantly on diabetes reversal.
The article is brief and explains the liver’s central role in diabetes progression, separate from muscle cells. As fat accumulates in the liver, pancreatic beta cells are also affected and are unable to carry on their role with efficiency.
It can now be seen that muscle insulin resistance is a factor which expedites the accumulation of liver fat during the phase of developing the condition.
My assumption so far is that this knowledge is not widespread across the medical profession.
And neither is this:
The good news for people with type 2 diabetes is that they have a potentially reversible metabolic condition. Large numbers of individuals who are strongly motivated have now returned their metabolic state to normal, and are off all medication.
This is all connected to metabolic syndrome, dyslipidemia, and ultimately diet, and so the lipid changes presented in the DIETFITS study last week come into focus as somewhat concerning for the low fat group, relative to the low carb group (e.g. they are not the same).
Following up at #LCB18 where I hope to learn if my assessment is valid. If not, I’ll post again here.
Citation: Taylor R. Putting insulin resistance into context by dietary reversal of type 2 diabetes. J R Coll Physicians Edinb [Internet]. 2017 Jun [cited 2018 Feb 18];47(2):168–71. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28675193